Background: Few studies have linked major dietary nutrient patterns to chronic diseases. Despite the growing evidence on the association between dietary patterns and obesity, we are aware of no study that examined the association between patterns of nutrient intake and obesity.Objective: To identify major nutrient patterns in Iranian adults and investigate their association with general and abdominal obesity.Methods: In this cross-sectional study, dietary data were collected using a validated dish-based 106-item semiquantitative food frequency questionnaire in 8691 subjects aged 18-55 years. Complete data of 6724 and 5203 adults were available for general and abdominal obesity, respectively. Data on anthropometric measures were collected through a self-administered questionnaire. General obesity was defined as body mass index≥30 kg/m2 and abdominal obesity was defined as waist circumference> 102 for men and>88 cm for women. Daily intakes of 38 nutrients and bioactive compounds for each participant were calculated. Principal component analysis was applied to derive major nutrient patterns.Results: Three major nutrient patterns were identified: 1) pattern 1 was high in fatty acids (including saturated, mono and poly-unsaturated fatty acids), cholesterol, vitamin B12, vitamin E, zinc, choline, protein, pyridoxine, phosphorus, and pantothenic acid.; 2) pattern 2 was high in thiamine, betaine, starch, folate, iron, selenium, niacin, calcium, and manganese, and 3) pattern 3 was high in glucose, fructose, sucrose, vitamin C, potassium, total dietary fiber, selenium and vitamin K. Men in the highest quintile of pattern 2 were less likely to be generally obese in the fully adjusted model (Odds ratio (OR): 0.39, 95% confidence interval (CI): 0.20-0.76). After adjustment for potential confounders, a significant positive association was observed between pattern 3 and general obesity among men (OR: 1.77; 95%CI: 1.04-3.04), but not in women (OR: 1.18; 95% CI: 0.74-1.88). No overall association was seen between patterns of nutrient intake and abdominal obesity in either gender.Conclusion: Major nutrient patterns were significantly associated with general, but not abdominal obesity in the Iranian population. Further studies in other populations along with future prospective studies are required to confirm these findings.